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The permeability transition pore complex in cancer cell death

Oncogene volume 25, pages 4744–4756 (2006)Cite this article

A Corrigendum to this article was published on 26 October 2006

Abstract

The permeability transition pore (PTP) is a multi-protein complex at contact sites of the inner with the outer mitochondrial membrane. Research over the past years has led to the concept that the PTP occupies a central role in cell death induction. Numerous apoptosis signals convert this protein aggregate into an unspecific pore, thus activating mitochondria for the cellular self-destruction process. Here, we describe the evidence for this and the various approaches being undertaken to elucidate its subunit composition and mode of regulation. In particular, we review data that indicate a role of specific PTP subunits for apoptosis inhibition during tumorigenesis.

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Abbreviations

ADP:

adenosine diphosphate

ANT:

adenine nucleotide translocase

ATP:

adenosine 5′ triphosphate

Atr:

atractyloside

BA:

bongrekic acid

CK:

creatine kinase

CsA:

cyclosporin A

CypD:

Cyclophilin D

ΔΨm:

inner transmembrane potential

HK:

hexokinase

IM:

inner membrane

MEF:

mouse embryonic fibroblasts

OM:

outer membrane

PBR:

peripheral benzodiazepine receptor

PT:

permeability transition

PTP:

permeability transition pore

ROS:

reactive oxygen species

t-BHP:

tert-butylhydroperoxide

TNF:

tumor necrosis factor

VDAC:

voltage-dependent anion channel

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Acknowledgements

This work was supported by grants funded by ARC, La Ligue contre le Cancer and the Ministère délégué à la Recherche et aux Nouvelles Technologies (MRNT) (Subvention Genhomme, Convention 03L297) (to CB) and the Wellcome Trust and Cancer Research UK (to SG).

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  1. University of Versailles/St Quentin, CNRS UMR 8159, Versailles, France

    C Brenner

  2. Imperial College London, W12 ONN, Hammersmith Campus, London, UK

    S Grimm

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  1. C Brenner
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  2. S Grimm
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Correspondence to C Brenner.

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Brenner, C., Grimm, S. The permeability transition pore complex in cancer cell death. Oncogene 25, 4744–4756 (2006). https://doi.org/10.1038/sj.onc.1209609

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  • DOI: https://doi.org/10.1038/sj.onc.1209609

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