Issue 1, 2011
From the journal:

Chemical Communications

Identification of dihydropyridines that reduce cellular tau levels†

Christopher G. Evans,a   Umesh K. Jinwal,b   Leah N. Makley,a   Chad A. Dickeyb  and  Jason E. Gestwicki*a  

* Corresponding authors

a Department of Pathology and the Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, USA
E-mail: gestwick@umich.edu
Tel: +1 734-615-9537

b Department of Molecular Medicine, University of South Florida, 4001 E. Fletcher Ave., MDC 36, Tampa, USA
E-mail: cdickey@health.usf.edu
Tel: +1 813-396-0639

Abstract

A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure–activity relationships.

Graphical abstract: Identification of dihydropyridines that reduce cellular tau levels

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Article information

DOI
https://doi.org/10.1039/C0CC02253E
Article type
Communication
Submitted
30 Jun 2010
Accepted
04 Oct 2010
First published
16 Nov 2010

Chem. Commun., 2011,47, 529-531

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Identification of dihydropyridines that reduce cellular tau levels

C. G. Evans, U. K. Jinwal, L. N. Makley, C. A. Dickey and J. E. Gestwicki, Chem. Commun., 2011, 47, 529 DOI: 10.1039/C0CC02253E

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