The ligands/activators for peroxisome proliferator-activated receptor α (PPARα) and PPARγ increase Cu2+, Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells☆
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Targeting PPARs for therapy of atherosclerosis: A review
2023, International Journal of Biological MacromoleculesNeuroprotective effect of PPAR alpha and gamma agonists in a mouse model of amyloidogenesis through modulation of the Wnt/beta catenin pathway via targeting alpha- and beta-secretases
2020, Progress in Neuro-Psychopharmacology and Biological PsychiatryDocosahexaenoic acid inhibits TNFα-induced ICAM-1 expression by activating PPARα and autophagy in human endothelial cells
2019, Food and Chemical ToxicologyAlzheimer's disease-like pathology-triggered oxidative stress, alterations in monoamines levels, and structural damage of locus coeruleus neurons are partially recovered by a mix of proteoglycans of embryonic genesis
2019, Neurochemistry InternationalCitation Excerpt :Pretreatment of neurons with NE before amyloid exposure increases neuronal GSH level and upregulates expression and activation of peroxisome proliferator-activated receptors (PPARs) (Klotz et al., 2003; Madrigal et al., 2007). Interestingly, quantitative PCR analyses did not show any significant NE-dependent increase in either catalase or SOD mRNA levels (Madrigal et al., 2007), but PPARs activation leads to the stimulation of the expression of antioxidant enzymes (Girnun et al., 2002; Inoue et al., 2001). In addition, there are data that NE reduces the production of reactive oxygen species, serving as the first line of defense against oxidative stress (Dimić et al., 2017; Smythies, 2000) Neuroprotective effect of NE was also shown on the transgenic mouse model of AD, where the precursor of NE, L-threo-3,4-dihydroxyphenylserine (L-DOPS) improved memory and reduced Aβ plaque pathology (Kalinin et al., 2012), and the use of α2 adrenoblocker mesedin had a neuroprotective effect (Melkonyan et al., 2017).
Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress
2018, Free Radical Biology and Medicine
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Supported by the Japan Health Sciences Foundation for Research on Health Sciences focusing on Drug Innovation.