Regular ArticlesMechanisms of Syncytial Fusion: A Review
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2023, Reproductive BiologyThe effect of the delta SARS-CoV-2 variant on maternal infection and pregnancy
2022, iScienceCitation Excerpt :Using a process called syncytialization, the cytotrophoblasts fuse with the overlying giant multinucleated syncytiotrophoblasts and form the outer layer of the placental microvilli (Burton and Fowden, 2015; Robbins and Bakardjiev, 2012) rendering the tissue impermeable and enabling mother–child immune tolerance (Alasadi et al., 2019). The cytotrophoblasts may regenerate the syncytiotrophoblast if damaged, but if the process is significantly compromised, pathological conditions such as preeclampsia and intra-uterine fetal growth restriction (FGR) might ensue (Huppertz and Kingdom, 2004; Pötgens et al., 2002; Sankar et al., 2012). Increased numbers of syncytial knots, as seen in the placenta under conditions of hypoxia, hyperoxia, or in the presence of reactive oxygen species (ROS) (Heazell et al., 2007), and in preeclampsia (Redline and Patterson, 1995), were also observed with COVID-19 (Singh et al., 2021; Gao et al., 2021).
Renin-angiotensin system (RAS) enzymes and placental trophoblast syncytialisation
2022, Molecular and Cellular Endocrinology
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