Journal of the American Academy of Child & Adolescent Psychiatry
NEW RESEARCHMorphometric Brain Abnormalities in Boys With Conduct Disorder
Section snippets
Sample
Because the broad majority of CD individuals are males and to rule out sex-specific differences in brain structures, only boys were included in this study.24 In total, thirty 12- to 17-year-old male white adolescents diagnosed with the childhood-onset type of CD participated in our investigation. Seven of them had to be excluded because of movement artifacts during scanning (see below). The remaining 23 subjects were analyzed in this study. Twenty-three control subjects were recruited by board
RESULTS
The clinical and control groups were matched for age and IQ (Table 1). Seventeen (74%) of the 23 subjects investigated by MRI scanning also met the criteria for ADHD. No differences in age or IQ were found between the groups using a two-tailed t test.
DISCUSSION
In this study, we investigated regional differences in gray matter volumes of twenty-three 12- to 17-year-old boys with CD (17 of whom also met the criteria for ADHD) compared with 23 healthy control subjects. We performed a VBM analysis of the whole brain to assess anatomical correlates of CD and ADHD instead of using the hypothesis-driven manual measurement of single structures. In addition, subjects were examined twice, once each in childhood and adolescence, to verify the childhood-onset
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Accepted October 28, 2007, under the Editorship of Mina K. Dulcan, M.D.
Drs. Huebner and Vloet contributed equally to the manuscript.
This research was supported by DFG funding (HE 2660/3-2).
A poster appended to this study was presented at the 17th World Congress of the International Association for Child and Adolescent Psychiatry and Allied Professions (IACAPAP) 2006 in Melbourne, Australia, and received an award.
Disclosure: Dr. Herpertz-Dahlmann is a consultant to Eli Lilly and has received research funding from AstraZeneca, Eli Lilly, Novartis, and Janssen Cilag. The other authors report no conflicts of interest.