Abstract
Innocuous cooling or heating of the forearm can evoke nociceptive sensations, such as burning, stinging, and pricking (low-threshold thermal nociception, LTN), that are inhibited by dynamic contact. In the present study, I investigated whether LTN can also be perceived on the hand, and if so, whether it is normally suppressed by active touching. Innocuous cold (28°, 25°, and 18°C) and warm (38°, 40°, and 43°C) temperatures were delivered to the distal metacarpal pads and intermediate and distal phalanges of the fingers via a handgrip thermode that subjects either statically held or actively grasped. The same temperatures were delivered to the forearm via another thermode that either rested on the arm or was touched to the arm. Subjects rated the intensity of thermal (warmth, cold) and nociceptive (e.g., burning) sensations and indicated the qualities of sensation experienced. The results showed that LTN can be perceived on the hand, although less frequently and less intensely than on the forearm. Dynamic contact inhibited nociceptive and thermal sensations on the hand, although less strongly than on the forearm. These findings indicate that temperature perception on the hand is attenuated and its quality is changed when thermal stimulation is accompanied by dynamic tactile stimulation, as it is during haptic exploration.
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Adair, E. R. (1977). Skin, preoptic, and core temperatures influence behavioral thermoregulation. Journal of Applied Physiology, 42, 559–564.
Bartoshuk, L. M., Duffy, V. B., Fast, K., Green, B. G., Prutkin, J., & Snyder, D. J. (2003). Labeled scales (e.g., category, Likert, VAS) and invalid across-group comparisons: What we have learned from genetic variation in taste. Food Quality & Preference, 14, 125–138.
Bessou, P., & Perl, E. R. (1969). Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. Journal of Neurophysiology, 32, 1025–1043.
Bini, G., Cruccu, G., Hagbarth, K.-E., Shady, W., & Torebjörk, E. (1984). Analgesic effect of vibration and cooling on pain induced by intraneural electrical stimulation. Pain, 18, 239–248.
Burton, H., Terashima, S. I., & Clark, J. (1972). Response properties of slowly adapting mechanoreceptors to temperature stimulation in cats. Brain Research, 45, 401–416.
Cain, W. S. (1973). Spatial discrimination of cutaneous warmth. American Journal of Psychology, 86, 169–181.
Chapman, C. E., & Beauchamp, E. (2006). Differential controls over tactile detection in humans by motor commands and peripheral reafference. Journal of Neurophysiology, 96, 1664–1675.
Chung, M. K., Lee, H., & Caterina, M. J. (2003). Warm temperatures activate TRPV4 in mouse 308 keratinocytes. Journal of Biological Chemistry, 278, 32037–32046.
Chung, M. K., Lee, H., Mizuno, A., Suzuki, M., & Caterina, M. J. (2004). TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. Journal of Biological Chemistry, 279, 21569–21575.
Cliff, M. A., & Green, B. G. (1994). Sensory irritation and coolness produced by menthol: Evidence for selective desensitization of irritation. Physiology & Behavior, 56, 1021–1029.
Colburn, R. W., Lubin, M. L., Stone, D. J., Jr., Wang, Y., Lawrence, D., D’Andrea, M. R., et al. (2007). Attenuated cold sensitivity in TRPM8 null mice. Neuron, 54, 379–386.
Craig, J. C., & Rollman, G. B. (1999). Somesthesis. Annual Review of Psychology, 50, 305–331.
Dhaka, A., Murray, A. N., Mathur, J., Earley, T. J., Petrus, M. J., & Patapoutian, A. (2007). TRPM8 is required for cold sensation in mice. Neuron, 54, 371–378.
Dimmick, F. L. (1915). On the localization of pure warm sensations. American Journal of Psychology, 26, 142–150.
Doehring, K. M. (1989). Relieving pain through touch. Advancing Clinical Care, 4, 32–33.
Georgopoulos, A. P. (1976). Functional properties of primary afferent units probably related to pain mechanisms in primate glabrous skin. Journal of Neurophysiology, 39, 71–83.
Green, B. G. (1977). Localization of thermal sensation: An illusion and synthetic heat. Perception & Psychophysics, 22, 331–337.
Green, B. G. (1978). Referred thermal sensations: Warmth versus cold. Sensory Processes, 2, 220–230.
Green, B. G. (1979). Thermo-tactile interactions: Effects of touch on thermal localization. In D. R. Kenshalo (Ed.), Sensory functions of the skin of humans (pp. 223–240). New York: Plenum.
Green, B. G. (1992). The sensory effects of l-menthol on human skin. Somatosensory & Motor Research, 9, 235–244.
Green, B. G., & Akirav, C. (2007). Individual differences in temperature perception: Evidence of common processing of sensation intensity of warmth and cold. Somatosensory & Motor Research, 24, 71–84.
Green, B. G., & Pope, J. V. (2003). Innocuous cooling can produce nociceptive sensations that are inhibited during dynamic mechanical contact. Experimental Brain Research, 148, 290–299.
Green, B. G., Roman, C., Schoen, K., & Collins, H. (2008). Nociceptive sensations evoked from ‘spots’ in the skin by mild cooling and heating. Pain, 135, 196–208.
Green, B. G., & Schoen, K. L. (2005). Evidence that tactile stimulation inhibits nociceptive sensations produced by innocuous contact cooling. Behavioral Brain Research, 162, 90–98.
Green, B. G., & Schoen, K. L. (2007). Thermal and nociceptive sensations from menthol and their suppression by dynamic contact. Behavioral Brain Research, 176, 284–291.
Green, B. G., Shaffer, G. S., & Gilmore, M. M. (1993). Derivation and evaluation of a semantic scale of oral sensation magnitude with apparent ratio properties. Chemical Senses, 18, 683–702.
Green, B. G., & Zaharchuk, R. (2001). Spatial variation in sensitivity as a factor in measurements of spatial summation of warmth and cold. Somatosensory & Motor Research, 18, 181–190.
Hahn, J. F. (1971). Thermal-mechanical stimulus interactions in lowthreshold C-fiber mechanoreceptors of cat. Experimental Neurology, 33, 607–617.
Handwerker, H. O., Iggo, A., & Zimmermann, M. (1975). Segmental and supraspinal actions on dorsal horn neurons responding to noxious and non-noxious skin stimuli. Pain, 1, 147–165.
Harrison, J. L., & Davis, K. D. (1999). Cold-evoked pain varies with skin type and cooling rate: A psychophysical study in humans. Pain, 83, 123–135.
Hensel, H., & Zotterman, Y. (1951). The response of mechanoreceptors to thermal stimulation. Journal of Physiology, 115, 16–24.
Hutchison, W. D., Tsoukatos, J., & Dostrovsky, J. O. (1997). Quantitative analysis of orofacial thermoreceptive neurons in the superficial medullary dorsal horn of the rat. Journal of Neurophysiology, 77, 3252–3266.
Iannetti, G. D., Zambreanu, L., & Tracey, I. (2006). Similar nociceptive afferents mediate psychophysical and electrophysiological responses to heat stimulation of glabrous and hairy skin in humans. Journal of Physiology, 577, 235–248.
Inui, K., Tsuji, T., & Kakigi, R. (2006). Temporal analysis of cortical mechanisms for pain relief by tactile stimuli in humans. Cerebral Cortex, 16, 355–365.
Jones, F. N., Singer, D., & Twelker, P. A. (1962). Interactions among the somesthetic senses in judgments of subjective magnitude. Journal of Experimental Psychology, 64, 105–109.
Kadohisa, M., Rolls, E. T., & Verhagen, J. V. (2004). Orbitofrontal cortex: Neuronal representation of oral temperature and capsaicin in addition to taste and texture. Neuroscience, 127, 207–221.
LaMotte, R. H., & Thalhammer, J. G. (1982). Response properties of high-threshold cutaneous cold receptors in the primate. Brain Research, 244, 279–287.
Longe, S. E., Wise, R., Bantick, S., Lloyd, D., Johansen-Berg, H., McGlone, F., & Tracey, I. (2001). Counter-stimulatory effects on pain perception and processing are significantly altered by attention: An fMRI study. NeuroReport, 12, 2021–2025.
Melzack, R., & Wall, P. D. (1965). Pain mechanisms: A new theory. Science, 150, 971–979.
Milne, R. J., Aniss, A. M., Kay, N. E., & Gandevia, S. C. (1988). Reduction in perceived intensity of cutaneous stimuli during movement: A quantitative study. Experimental Brain Research, 70, 569–576.
Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S., et al. (2005). Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science, 307, 1468–1472.
Nelson, R. J. (1996). Interactions between motor commands and somatic perception in sensorimotor cortex. Current Opinion in Neurobiology, 6, 801–810.
Okazawa, M., Inoue, W., Hori, A., Hosokawa, H., Matsumura, K., & Kobayashi, S. (2004). Noxious heat receptors present in cold-sensory cells in rats. Neuroscience Letters, 359, 33–36.
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., et al. (2002). A TRP channel that senses cold stimuli and menthol. Cell, 108, 705–715.
Pertovaara, A. (1979). Modification of human pain threshold by specific tactile receptors. Acta Physiologica Scandinavica, 107, 339–341.
Price, D. D., & Dubner, R. (1977). Neurons that subserve the sensorydiscriminative aspects of pain. Pain, 3, 307–338.
Ross, H. E., & Murray, D. J. (1978). E. H. Weber: The sense of touch. New York: Academic Press.
Sandkühler, J. (1996). The organization and function of endogenous antinociceptive systems. Progress in Neurobiology, 50, 49–81.
Simone, D. A., & Kajander, K. C. (1996). Excitation of rat cutaneous nociceptors by noxious cold. Neuroscience Letters, 213, 53–56.
Simone, D. A., & Kajander, K. C. (1997). Responses of cutaneous A-fiber nociceptors to noxious cold. Journal of Neurophysiology, 77, 2049–2060.
Smith, G. D., Gunthorpe, M. J., Kelsell, R. E., Hayes, P. D., Reilly, P., Facer, P., et al. (2002). TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature, 418, 186–190.
Stevens, J. C., & Green, B. G. (1978). Temperature—touch interaction: Weber’s phenomenon revisited. Sensory Processes, 2, 206–219.
Taus, R. H., Stevens, J. C., & Marks, L. E. (1975). Spatial localization of warmth. Perception & Psychophysics, 17, 194–196.
Taylor, D. J., McGillis, S. L., & Greenspan, J. D. (1993). Body site variation of heat pain sensitivity. Somatosensory & Motor Research, 10, 455–465.
Tillman, D. B., Treede, R. D., Meyer, R. A., & Campbell, J. N. (1995). Response of C fibre nociceptors in the anaesthetized monkey to heat stimuli: Correlation with pain threshold in humans. Journal of Physiology, 485, 767–774.
Todaka, H., Taniguchi, J., Satoh, J., Mizuno, A., & Suzuki, M. (2004). Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia. Journal of Biological Chemistry, 279, 35133–35138.
Treede, R. D., Meyer, R. A., Raja, S. N., & Campbell, J. N. (1995). Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. Journal of Physiology, 483, 747–758.
Tsuboi, Y., Iwata, K., Muramatsu, H., Yagi, J., Inomata, Y., & Sumino, R. (1993). Response properties of primary somatosensory cortical neurons responsive to cold stimulation of the facial skin and oral mucous membrane. Brain Research, 613, 193–202.
VanDoorn, G. H., Richardson, B. L., Wuillemin, D. B., & Symmons, M. A. (2005). Modification of magnitude estimations in thermotactile perception during self-generated and externally generated movements. Perception, 34, 231–235.
Wall, P. D. (1978). The gate control theory of pain mechanisms. A reexamination and re-statement. Brain, 101, 1–18.
Wall, P. D., & Cronly-Dillon, J. R. (1960). Pain, itch, and vibration. Archives of Neurology, 2, 365–375.
Wasner, G., Schattschneider, J., Binder, A., & Baron, R. (2004). Topical menthol—a human model for cold pain by activation and sensitization of C nociceptors. Brain, 127, 1159–1171.
Xu, H., Ramsey, I. S., Kotecha, S. A., Moran, M. M., Chong, J. A., Lawson, D., et al. (2002). TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature, 418, 181–186.
Yarnitsky, D., Kunin, M., Brik, R., & Sprecher, E. (1997). Vibration reduces thermal pain in adjacent dermatomes. Pain, 69, 75–77.
Ya-Xian, Z., Suetake, T., & Tagami, H. (1999). Number of cell layers of the stratum corneum in normal skin: Relationship to the anatomical location on the body, age, sex and physical parameters. Archives of Dermatological Research, 291, 555–559.
Zanotto, K. L., Merrill, A. W., Carstens, M. I., & Carstens, E. (2007). Neurons in superficial trigeminal subnucleus caudalis responsive to oral cooling, menthol, and other irritant stimuli. Journal of Neurophysiology, 97, 966–978.
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Thisresearch was supported in part by National Institutes of Health Grant RO1 NS38463.
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Green, B.G. Temperature perception on the hand during static versus dynamic contact with a surface. Attention, Perception, & Psychophysics 71, 1185–1196 (2009). https://doi.org/10.3758/APP.71.5.1185
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DOI: https://doi.org/10.3758/APP.71.5.1185