Abstract
Stimulation-evoked 3H-noradrenaline release in human cerebrocortical slices was inhibited by histamine (in a manner sensitive to clobenpropit) and by imetit, suggesting H3 receptor-mediated inhibition of noradrenaline release in human brain.
MeSH terms
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Animals
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Brain / drug effects
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Brain / metabolism*
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Cerebral Cortex / drug effects
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Cerebral Cortex / metabolism
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Dimethindene / pharmacology
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Electric Stimulation
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Hippocampus / drug effects
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Hippocampus / metabolism
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Histamine / pharmacology
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Histamine Agonists / pharmacology
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Histamine Antagonists / pharmacology
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Humans
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Imidazoles / pharmacology
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Male
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Mice
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Mice, Inbred Strains
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Norepinephrine / metabolism*
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Piperidines / pharmacology
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Ranitidine / pharmacology
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Receptors, Histamine H3 / physiology*
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Thiourea / analogs & derivatives
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Thiourea / pharmacology
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Tritium / metabolism
Substances
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Histamine Agonists
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Histamine Antagonists
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Imidazoles
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Piperidines
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Receptors, Histamine H3
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Tritium
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Dimethindene
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imetit
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Histamine
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Ranitidine
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Thiourea
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thioperamide
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clobenpropit
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Norepinephrine