WNT targets. Repression and activation

Trends Genet. 1999 Jan;15(1):1-3. doi: 10.1016/s0168-9525(98)01634-5.

Abstract

Several puzzling observations made previously suggested that target genes that are activated by WNT signaling during development were actively repressed in the absence of the signal. Recent work sheds light on how this switch between repression and activation is regulated.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / embryology
  • Caenorhabditis elegans / genetics
  • Drosophila Proteins*
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics
  • Embryonic Development
  • Gene Expression Regulation, Developmental / genetics
  • Gene Expression Regulation, Developmental / physiology*
  • Helminth Proteins / genetics
  • Helminth Proteins / physiology
  • Insect Proteins / genetics
  • Insect Proteins / physiology
  • Models, Genetic
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*
  • Repressor Proteins / genetics
  • Repressor Proteins / physiology
  • Signal Transduction / physiology*
  • Transcription Factors / physiology
  • Wnt Proteins
  • Xenopus laevis / embryology
  • Xenopus laevis / growth & development
  • Zebrafish Proteins*

Substances

  • Drosophila Proteins
  • Helminth Proteins
  • Insect Proteins
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Transcription Factors
  • Wnt Proteins
  • Zebrafish Proteins
  • pan protein, Drosophila