Abstract
gamma-aminobutyric acid (GABA)-containing fibers from the nucleus accumbens shell (AcbSh) terminate in the medial ventral pallidum (VPm) and neurons in the VPm project to the lateral hypothalamus (LH). Therefore, the VPm is anatomically interposed between the AcbSh and LH, two functionally related brain regions that mediate food intake. The present study demonstrates that blockade of GABAA receptors in the VPm by local administration of bicuculline greatly increases food intake in satiated rats. The data suggest that an AcbSh-VPm-LH circuit may be involved in the control of feeding behavior.
Copyright 1999 Published by Elsevier Science B.V.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Bicuculline / pharmacology*
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Dose-Response Relationship, Drug
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Drinking
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Eating
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Feeding Behavior / drug effects
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Feeding Behavior / physiology
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GABA Antagonists / pharmacology*
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Globus Pallidus / chemistry
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Globus Pallidus / cytology
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Globus Pallidus / physiology*
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Hypothalamic Area, Lateral / chemistry
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Hypothalamic Area, Lateral / cytology
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Hypothalamic Area, Lateral / physiology
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Male
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Neural Pathways
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Nucleus Accumbens / chemistry
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Nucleus Accumbens / cytology
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Nucleus Accumbens / physiology
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Rats
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Rats, Sprague-Dawley
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Receptors, GABA-A / physiology*
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Satiation / drug effects*
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Satiation / physiology
Substances
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GABA Antagonists
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Receptors, GABA-A
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Bicuculline