Abstract
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are predominantly nuclear RNA-binding proteins that form complexes with RNA polymerase II transcripts. These proteins function in a staggering array of cellular activities, ranging from transcription and pre-mRNA processing in the nucleus to cytoplasmic mRNA translation and turnover. Recent studies suggest that several fundamental characteristics of hnRNPs account for their involvement in multiple regulatory pathways.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Base Sequence
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Heterogeneous-Nuclear Ribonucleoproteins
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Humans
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RNA Precursors / genetics
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RNA Processing, Post-Transcriptional
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA-Binding Proteins / chemistry
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RNA-Binding Proteins / physiology*
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Ribonucleoproteins / chemistry
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Ribonucleoproteins / physiology*
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Transcription, Genetic
Substances
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Heterogeneous-Nuclear Ribonucleoproteins
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RNA Precursors
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RNA, Messenger
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RNA-Binding Proteins
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Ribonucleoproteins