Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats

Brain Res Mol Brain Res. 1999 Jul 5;70(2):298-303. doi: 10.1016/s0169-328x(99)00165-5.

Abstract

Adult motoneurons can survive following axotomy, whereas neonate motoneurons result in cell death. Following hypoglossal nerve axotomy in neonate rat, Glial cell line-Derived Neurotrophic Factor (GDNF) receptor alpha-1 (GFRalpha-1) mRNA expression was dramatically suppressed in the injured motoneurons, while a slight increase of c-Ret mRNA expression was observed. In adult, both GFRalpha-1 and c-Ret mRNAs increased substantially after axotomy. The present result suggests that the difference of motoneuron fate after axotomy may be partly due to the coordinate or discordant responses of GFRalpha-1 and c-Ret expression to nerve injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Animals
  • Animals, Newborn
  • Axotomy
  • Brain / growth & development
  • Brain / metabolism*
  • Drosophila Proteins*
  • Gene Expression Regulation, Developmental / physiology*
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Hypoglossal Nerve / physiology*
  • Hypoglossal Nerve Injuries*
  • Male
  • Motor Neurons / metabolism*
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-ret
  • RNA, Messenger / genetics
  • Rats
  • Rats, Wistar
  • Receptor Protein-Tyrosine Kinases / genetics*
  • Reference Values
  • Transcription, Genetic

Substances

  • Drosophila Proteins
  • Gfra1 protein, rat
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases
  • Ret protein, Drosophila
  • Ret protein, rat