Abstract
Adult motoneurons can survive following axotomy, whereas neonate motoneurons result in cell death. Following hypoglossal nerve axotomy in neonate rat, Glial cell line-Derived Neurotrophic Factor (GDNF) receptor alpha-1 (GFRalpha-1) mRNA expression was dramatically suppressed in the injured motoneurons, while a slight increase of c-Ret mRNA expression was observed. In adult, both GFRalpha-1 and c-Ret mRNAs increased substantially after axotomy. The present result suggests that the difference of motoneuron fate after axotomy may be partly due to the coordinate or discordant responses of GFRalpha-1 and c-Ret expression to nerve injury.
Copyright 1999 Elsevier Science B.V.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aging
-
Animals
-
Animals, Newborn
-
Axotomy
-
Brain / growth & development
-
Brain / metabolism*
-
Drosophila Proteins*
-
Gene Expression Regulation, Developmental / physiology*
-
Glial Cell Line-Derived Neurotrophic Factor Receptors
-
Hypoglossal Nerve / physiology*
-
Hypoglossal Nerve Injuries*
-
Male
-
Motor Neurons / metabolism*
-
Proto-Oncogene Proteins / genetics*
-
Proto-Oncogene Proteins c-ret
-
RNA, Messenger / genetics
-
Rats
-
Rats, Wistar
-
Receptor Protein-Tyrosine Kinases / genetics*
-
Reference Values
-
Transcription, Genetic
Substances
-
Drosophila Proteins
-
Gfra1 protein, rat
-
Glial Cell Line-Derived Neurotrophic Factor Receptors
-
Proto-Oncogene Proteins
-
RNA, Messenger
-
Proto-Oncogene Proteins c-ret
-
Receptor Protein-Tyrosine Kinases
-
Ret protein, Drosophila
-
Ret protein, rat