Abstract
Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine triphosphatase-activating proteins (GAPs) for heterotrimeric G protein alpha subunits - the "regulator of G protein signaling" or RGS proteins. In considering both documented and potential functions of several RGS protein family members with demonstrable multidomain compositions (p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D-AKAP2, the G protein-coupled receptor kinases [GRKs], the DEP/GGL/RGS subfamily [RGS6, RGS7, RGS9, RGS11], and RGS12), this review explores the shift in our appreciation of the RGS proteins from unidimensional desensitizing agents to multifocal signal transduction regulators.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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A Kinase Anchor Proteins
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Adaptor Proteins, Signal Transducing*
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Amino Acid Sequence
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Animals
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Axin Protein
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Carrier Proteins / physiology
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Cell Cycle / physiology
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Cyclic AMP-Dependent Protein Kinases / physiology
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Cytoskeletal Proteins / physiology
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Fungal Proteins / physiology
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GTP-Binding Proteins / physiology
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Humans
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Models, Biological
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Molecular Sequence Data
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Protein-Tyrosine Kinases / physiology
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Proteins / physiology
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RGS Proteins / metabolism*
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RGS Proteins / physiology*
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Repressor Proteins*
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Sequence Homology, Amino Acid
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Signal Transduction*
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rho GTP-Binding Proteins / physiology
Substances
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A Kinase Anchor Proteins
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AKAP10 protein, human
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AXIN2 protein, human
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Adaptor Proteins, Signal Transducing
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Axin Protein
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Carrier Proteins
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Cytoskeletal Proteins
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Fungal Proteins
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Proteins
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RGS Proteins
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Repressor Proteins
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Protein-Tyrosine Kinases
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Cyclic AMP-Dependent Protein Kinases
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GTP-Binding Proteins
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rho GTP-Binding Proteins