Abstract
EphA7 is a receptor tyrosine kinase of the Eph family. We have mapped EphA7 immunoreactivity and ligand binding in mouse embryo heads and developing brain. Immunoreactivity for the full-length receptor is found in all the cell populations that express EphA7 mRNA. In particular, it is located on growing axons from EphA7-expressing neurons, both in the trigeminal nerve and in developing brain. In many cases it persists in terminal fields in adult brain. Ligand is detected in a largely complementary distribution in embryos, but is surprisingly weak or undetectable in the target regions of many EphA7-positive axons postnatally.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Brain / embryology
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Brain / enzymology
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Brain / growth & development
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Embryo, Mammalian / enzymology
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Gene Expression Regulation, Developmental
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Gene Expression Regulation, Enzymologic
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Immunohistochemistry
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In Situ Hybridization
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Ligands
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Mice
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Nervous System / embryology
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Nervous System / enzymology*
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Nervous System / growth & development
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RNA, Messenger / genetics
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Receptor Protein-Tyrosine Kinases / genetics*
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Receptor Protein-Tyrosine Kinases / metabolism
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Receptor, EphA7
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Spinal Cord / embryology
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Spinal Cord / enzymology
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Spinal Cord / growth & development
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Tissue Distribution
Substances
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Ligands
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RNA, Messenger
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Receptor Protein-Tyrosine Kinases
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Receptor, EphA7