Appearance of frontal midline theta activity in patients with generalized anxiety disorder

Neuropsychobiology. 2000 Jan;41(2):108-12. doi: 10.1159/000026641.

Abstract

The appearance of frontal midline theta activity (Fmθ), recognized as distinct EEG theta rhythm in the frontal midline area during performance of a mental task, reflects feelings of relief from anxiety in humans. In the present study, EEGs were recorded, and the Hamilton Rating Scale for Anxiety and the state anxiety scale of Spielberger's State-Trait Anxiety Inventory were evaluated once a week in 28 patients with generalized anxiety disorder. The Taylor Manifest Anxiety Scale and the trait anxiety scale of Spielberger's State-Trait Anxiety Inventory were used to assess anxiety before and after the tests. The present results suggest that the appearance of Fmθ might be closely related to an improvement in the anxiety symptoms associated with generalized anxiety disorder.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Anxiety Agents / administration & dosage
  • Anxiety Disorders / diagnosis*
  • Anxiety Disorders / drug therapy
  • Anxiety Disorders / physiopathology
  • Arousal / drug effects
  • Arousal / physiology
  • Electroencephalography* / drug effects
  • Female
  • Frontal Lobe / drug effects
  • Frontal Lobe / physiopathology*
  • Humans
  • Hypnotics and Sedatives / administration & dosage
  • Male
  • Middle Aged
  • Personality Inventory
  • Problem Solving / drug effects
  • Problem Solving / physiology
  • Theta Rhythm*

Substances

  • Anti-Anxiety Agents
  • Hypnotics and Sedatives