Abstract
Short-term synaptic plasticity has a key role in information processing in the CNS, whereas memories can be formed through long-lasting changes in synaptic strength. Despite the importance of these phenomena, it remains difficult to determine whether a synaptic modulation is expressed at a presynaptic or postsynaptic site. This article describes a new approach that, in its simplest form, can identify the site of expression by direct graphical means. A more-sophisticated form of the technique can quantify functional synaptic properties and determine which of these properties is altered following a modulation of synaptic strength.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
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Anesthetics, Local / pharmacology
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Animals
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Baclofen / pharmacology
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Cells, Cultured
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Computer Graphics
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Data Display*
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Excitatory Amino Acid Antagonists / pharmacology
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Excitatory Postsynaptic Potentials / physiology
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GABA Agonists / pharmacology
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Lidocaine / analogs & derivatives
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Lidocaine / pharmacology
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Mathematical Computing
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Memory / physiology
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Models, Neurological
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Neuronal Plasticity / physiology*
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Neurons / cytology
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Neurons / drug effects
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Neurons / physiology*
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Rats
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Regression Analysis
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Signal Processing, Computer-Assisted
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Synapses / drug effects
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Synapses / metabolism*
Substances
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Anesthetics, Local
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Excitatory Amino Acid Antagonists
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GABA Agonists
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QX-314
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6-Cyano-7-nitroquinoxaline-2,3-dione
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Lidocaine
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Baclofen