Abstract
Our understanding of neuronal synapse development has advanced in recent years. The development of glycinergic synapses appears to depend on gephyrin and glycine receptor activity. Molecular characterization of the structure and development of glutamatergic synapses is in progress, but the underlying mechanisms remain unclear. Activity-dependent mechanisms and specific molecules that regulate the morphological development of dendritic spines have recently been identified.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Dendrites / metabolism
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Humans
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Motor Endplate / chemistry
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Motor Endplate / metabolism
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Nerve Growth Factors / metabolism
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Nerve Growth Factors / physiology
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Nerve Tissue Proteins / metabolism
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Nervous System / cytology*
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Nervous System / growth & development
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Nervous System / metabolism
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Neurons / cytology*
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Neurons / metabolism
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Receptors, Glutamate / metabolism
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Synapses / chemistry
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Synapses / metabolism
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Synapses / physiology*
Substances
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Nerve Growth Factors
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Nerve Tissue Proteins
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Receptors, Glutamate