Abstract
The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Actins / metabolism*
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Animals
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Cell Adhesion
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Cell Adhesion Molecules / metabolism
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Cell Movement
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Cytoskeleton / metabolism
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Drosophila Proteins
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Growth Cones / enzymology*
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Growth Cones / physiology*
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Phosphorylation
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Protein Binding
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Protein Tyrosine Phosphatases / metabolism
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Proto-Oncogene Proteins c-abl / metabolism*
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Receptor-Like Protein Tyrosine Phosphatases
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rho GTP-Binding Proteins / metabolism
Substances
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Actins
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Cell Adhesion Molecules
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Drosophila Proteins
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Proto-Oncogene Proteins c-abl
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Lar protein, Drosophila
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Protein Tyrosine Phosphatases
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Receptor-Like Protein Tyrosine Phosphatases
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rho GTP-Binding Proteins