Linking Hebb's coincidence-detection to memory formation

Curr Opin Neurobiol. 2000 Apr;10(2):266-73. doi: 10.1016/s0959-4388(00)00070-2.

Abstract

The theoretical foundations of learning and memory were laid by Donald Hebb 50 years ago. Recent genetic experiments that enhanced coincidence-detection of the NMDA receptor (a molecular master-switch in implementing Hebb's rule) and that led to better learning and memory in adult animals have substantially validated Hebb's rule in memory formation in the brain.

Publication types

  • Review

MeSH terms

  • Animals
  • Behavior, Animal / physiology
  • Learning / physiology*
  • Long-Term Potentiation / genetics*
  • Long-Term Potentiation / physiology
  • Memory / physiology*
  • Mice
  • Mice, Knockout
  • Mice, Neurologic Mutants
  • Models, Neurological
  • Neuronal Plasticity / physiology
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Time Perception / physiology*

Substances

  • Receptors, N-Methyl-D-Aspartate