Abstract
The theoretical foundations of learning and memory were laid by Donald Hebb 50 years ago. Recent genetic experiments that enhanced coincidence-detection of the NMDA receptor (a molecular master-switch in implementing Hebb's rule) and that led to better learning and memory in adult animals have substantially validated Hebb's rule in memory formation in the brain.
MeSH terms
-
Animals
-
Behavior, Animal / physiology
-
Learning / physiology*
-
Long-Term Potentiation / genetics*
-
Long-Term Potentiation / physiology
-
Memory / physiology*
-
Mice
-
Mice, Knockout
-
Mice, Neurologic Mutants
-
Models, Neurological
-
Neuronal Plasticity / physiology
-
Receptors, N-Methyl-D-Aspartate / physiology
-
Time Perception / physiology*
Substances
-
Receptors, N-Methyl-D-Aspartate