Abstract
Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are responsible for familial forms of PD and alpha-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with alpha-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aged, 80 and over
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Animals
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Antibodies
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Blotting, Western
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Carrier Proteins / analysis*
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Carrier Proteins / immunology
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Humans
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Lewy Bodies / chemistry*
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Lewy Bodies / pathology*
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Middle Aged
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Nerve Tissue Proteins / analysis*
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Nerve Tissue Proteins / immunology
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Neurons / pathology
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Parkinson Disease / pathology*
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Rabbits
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Substantia Nigra / pathology
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Synucleins
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alpha-Synuclein
Substances
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Antibodies
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Carrier Proteins
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Nerve Tissue Proteins
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SNCA protein, human
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SNCAIP protein, human
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Synucleins
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alpha-Synuclein