Cell replacement therapies for central nervous system disorders

Nat Neurosci. 2000 Jun;3(6):537-44. doi: 10.1038/75705.

Abstract

In animal models, immature neural precursors can replace lost neurons, restore function and promote brain self-repair. Clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain. But how realistic is it that cell replacement can be developed into effective clinical therapy?

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / cytology*
  • Brain / embryology
  • Cell Transplantation / methods
  • Cell Transplantation / trends*
  • Central Nervous System Diseases / therapy*
  • Clinical Trials as Topic
  • Epilepsy / therapy
  • Humans
  • Huntington Disease / therapy
  • Neurons / transplantation*
  • Parkinson Disease / therapy
  • Rats
  • Recovery of Function
  • Seizures / prevention & control
  • Stem Cell Transplantation*
  • Stroke / therapy
  • Swine