Abstract
Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I describe a timing-based, associative form of long-term potentiation and depression (LTP/LTD) at this synapse in S1. LTP occurred when excitatory postsynaptic potentials (EPSPs) led single postsynaptic action potentials (APs) within a narrow temporal window, and LTD occurred when APs led EPSPs within a significantly broader window. This long LTD window is unusual among timing-based learning rules and causes EPSPs that are uncorrelated with postsynaptic APs to become depressed. This behavior suggests a simple model for depression of deprived sensory responses in S1 and V1.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
2-Amino-5-phosphonovalerate / pharmacology
-
Animals
-
Electric Stimulation
-
Electrophysiology
-
Excitatory Amino Acid Antagonists / pharmacology
-
Excitatory Postsynaptic Potentials / drug effects
-
Excitatory Postsynaptic Potentials / physiology
-
Long-Term Potentiation / drug effects
-
Long-Term Potentiation / physiology*
-
Membrane Potentials / drug effects
-
Membrane Potentials / physiology
-
Neuronal Plasticity / drug effects
-
Neuronal Plasticity / physiology*
-
Patch-Clamp Techniques
-
Pyramidal Cells / drug effects
-
Pyramidal Cells / physiology*
-
Rats
-
Rats, Long-Evans
-
Receptors, N-Methyl-D-Aspartate / drug effects
-
Receptors, N-Methyl-D-Aspartate / physiology
-
Somatosensory Cortex / cytology
-
Somatosensory Cortex / drug effects
-
Somatosensory Cortex / physiology*
-
Synapses / physiology
-
Vibrissae / physiology
-
Vision, Monocular / physiology
Substances
-
Excitatory Amino Acid Antagonists
-
Receptors, N-Methyl-D-Aspartate
-
2-Amino-5-phosphonovalerate