Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

Neuron. 2000 Sep;27(3):419-22. doi: 10.1016/s0896-6273(00)00051-9.
No abstract available

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / enzymology*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / biosynthesis*
  • Animals
  • Aspartic Acid Endopeptidases / genetics
  • Aspartic Acid Endopeptidases / metabolism*
  • Endopeptidases / metabolism*
  • Humans
  • Macromolecular Substances
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / metabolism
  • Membrane Proteins / metabolism
  • Mice
  • Presenilin-1
  • Presenilin-2
  • Protein Processing, Post-Translational
  • Receptors, Notch
  • Signal Transduction

Substances

  • Amyloid beta-Peptides
  • Macromolecular Substances
  • Membrane Glycoproteins
  • Membrane Proteins
  • PSEN1 protein, human
  • PSEN2 protein, human
  • Presenilin-1
  • Presenilin-2
  • Receptors, Notch
  • nicastrin protein
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE2 protein, human
  • BACE1 protein, human
  • Bace1 protein, mouse