Abstract
The thalamic relay to neocortex is dynamically gated. The inhibitory interneuron, which we have studied in the lateral geniculate nucleus, is important to this process. In addition to axonal outputs, these cells have dendritic terminals that are both presynaptic and postsynaptic. Even with action potentials blocked, activation of ionotropic and metabotropic glutamate receptors on these terminals increases their output, whereas activation of metabotropic (M2 muscarinic) but not nicotinic cholinergic receptors decreases their output. These actions can strongly affect retinogeniculate transmission.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Action Potentials / drug effects
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Action Potentials / physiology
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Animals
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Calcium / metabolism
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Cats
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Cycloleucine / analogs & derivatives*
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Cycloleucine / pharmacology
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Dendrites / physiology*
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GABA Antagonists / pharmacology
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Geniculate Bodies / cytology
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Geniculate Bodies / drug effects
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Geniculate Bodies / physiology*
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Glutamic Acid / metabolism
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In Vitro Techniques
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Interneurons / cytology
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Interneurons / drug effects
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Interneurons / physiology*
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Magnesium / metabolism
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Magnesium / pharmacology
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Muscarinic Agonists / pharmacology
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Neural Inhibition / drug effects
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Neural Inhibition / physiology*
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Nicotinic Agonists / pharmacology
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Patch-Clamp Techniques
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Presynaptic Terminals / drug effects
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Presynaptic Terminals / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptors, Metabotropic Glutamate / agonists
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Receptors, Metabotropic Glutamate / metabolism
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Tetrodotoxin / pharmacology
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / metabolism
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / pharmacology
Substances
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GABA Antagonists
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Muscarinic Agonists
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Nicotinic Agonists
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Receptors, Metabotropic Glutamate
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Cycloleucine
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1-amino-1,3-dicarboxycyclopentane
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Glutamic Acid
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Tetrodotoxin
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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Magnesium
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Calcium