Abstract
Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G(1) to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in response to a large variety of intrinsic and extrinsic signals.
MeSH terms
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Animals
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Cell Cycle / physiology*
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Cyclin G
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Cyclin G1
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Cyclin-Dependent Kinase Inhibitor p21
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Cyclin-Dependent Kinases / antagonists & inhibitors
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Cyclin-Dependent Kinases / metabolism*
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Cyclins / metabolism*
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Enzyme Inhibitors / metabolism
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Mice
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Peptide Hydrolases / metabolism
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Phosphorylation
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Protein Folding
Substances
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Ccng1 protein, mouse
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Cdkn1a protein, mouse
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Cyclin G
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Cyclin G1
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Cyclin-Dependent Kinase Inhibitor p21
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Cyclins
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Enzyme Inhibitors
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Cyclin-Dependent Kinases
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Peptide Hydrolases