Abstract
A decade ago, chick-quail transplantation studies demonstrated that the junction between the midbrain and hindbrain has the properties of an organizing center capable of patterning the midbrain and cerebellum. Many of the genes that function to pattern these tissues have been identified and extensively studied. Recent experiments have shown that Otx2, Gbx2 and Fgf8 genes play a major role in the positioning and functioning of this organizing center.
MeSH terms
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Animals
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Body Patterning / genetics
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Brain / embryology
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Brain / metabolism*
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Cerebellum / embryology
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Cerebellum / metabolism
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Embryonic Induction / genetics
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Feedback / physiology
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Fibroblast Growth Factor 8
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Fibroblast Growth Factors / genetics
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Fibroblast Growth Factors / metabolism*
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Gene Expression Regulation, Developmental
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism*
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Mesencephalon / embryology
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Mesencephalon / metabolism
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Mice
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism*
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Organizers, Embryonic / metabolism*
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Otx Transcription Factors
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Prosencephalon / embryology
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Prosencephalon / metabolism
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Proto-Oncogene Proteins / metabolism
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Rhombencephalon / embryology
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Rhombencephalon / metabolism
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Trans-Activators / genetics
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Trans-Activators / metabolism*
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Wnt Proteins
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Zebrafish Proteins*
Substances
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Fgf8 protein, mouse
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Gbx2 protein, mouse
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Homeodomain Proteins
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Nerve Tissue Proteins
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Otx Transcription Factors
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Otx2 protein, mouse
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Proto-Oncogene Proteins
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Trans-Activators
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Wnt Proteins
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Zebrafish Proteins
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gbx2 protein, zebrafish
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Fibroblast Growth Factor 8
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Fibroblast Growth Factors