What does 'chromatin remodeling' mean?

Trends Biochem Sci. 2000 Nov;25(11):548-55. doi: 10.1016/s0968-0004(00)01689-3.

Abstract

The regulated alteration of chromatin structure, termed 'chromatin remodeling', can be accomplished by covalent modification of histones or by the action of ATP-dependent remodeling complexes. A variety of mechanisms can be used to remodel chromatin; some act locally on a single nucleosome and others act more broadly. It is critical to establish a direct connection between the remodeling events observed in vivo and the mechanistic capabilities of remodeling complexes in vitro.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / metabolism
  • Adenosine Triphosphate / metabolism
  • Animals
  • Chromatin / chemistry*
  • Chromatin / genetics
  • Chromatin / metabolism*
  • DNA-Binding Proteins
  • Deoxyribonucleases, Type II Site-Specific / genetics
  • Deoxyribonucleases, Type II Site-Specific / metabolism
  • Drosophila Proteins*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • HSP70 Heat-Shock Proteins / genetics
  • HSP70 Heat-Shock Proteins / metabolism
  • Histones / genetics
  • Histones / metabolism
  • Humans
  • Promoter Regions, Genetic*
  • RNA-Binding Proteins*
  • Ribonucleoprotein, U1 Small Nuclear / genetics
  • Ribonucleoprotein, U1 Small Nuclear / metabolism
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Yeasts / genetics

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Fungal Proteins
  • HSP70 Heat-Shock Proteins
  • Histones
  • ISWI protein
  • RNA-Binding Proteins
  • Ribonucleoprotein, U1 Small Nuclear
  • SWI4 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • snf protein, Drosophila
  • Adenosine Triphosphate
  • SCEI protein, S cerevisiae
  • Deoxyribonucleases, Type II Site-Specific
  • Adenosine Triphosphatases