Abstract
Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional cues that act as an attractant for some cell types and as a repellent for others. Several lines of evidence suggest that two classes of receptors, the deleted in colorectal cancer (DCC) family and the UNC-5 family, mediate the attractant and repellent response to netrin. Although netrins were first identified as diffusible long-range cues for developing axons, recent findings provide evidence that they also function as short-range cues close to the surface of the cells that produce them. This short-range function of netrin contributes to guiding neurite outgrowth and mediating cell-cell interactions during development and perhaps also in adults.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Axons / physiology
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / ultrastructure
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Caenorhabditis elegans Proteins*
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Cell Movement
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Diffusion
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Dose-Response Relationship, Drug
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Drosophila melanogaster / genetics
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Drosophila melanogaster / growth & development
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Drosophila melanogaster / metabolism
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Evolution, Molecular
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Eye Proteins / physiology
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Fetal Proteins / physiology
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Genes, DCC
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Helminth Proteins / genetics
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Helminth Proteins / physiology
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Humans
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Insect Proteins / genetics
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Insect Proteins / physiology
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Membrane Proteins / genetics
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Membrane Proteins / physiology
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Mice
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Mice, Knockout
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Models, Neurological
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Multigene Family
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Muscle Proteins / physiology
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Nerve Growth Factors / genetics
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Nerve Growth Factors / physiology*
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Nerve Tissue Proteins / physiology*
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Netrin Receptors
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Netrin-1
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Netrins
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Neuromuscular Junction / physiology
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Receptors, Cell Surface / physiology
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Receptors, Growth Factor / genetics
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Receptors, Growth Factor / physiology
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Retinal Ganglion Cells / physiology
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Species Specificity
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Stimulation, Chemical
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Tumor Suppressor Proteins
Substances
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Caenorhabditis elegans Proteins
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Eye Proteins
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Fetal Proteins
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Helminth Proteins
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Insect Proteins
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Membrane Proteins
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Muscle Proteins
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NTN4 protein, human
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Nerve Growth Factors
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Nerve Tissue Proteins
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Netrin Receptors
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Netrins
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Ntn4 protein, mouse
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Receptors, Cell Surface
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Receptors, Growth Factor
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Tumor Suppressor Proteins
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netrin-3
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UNC-5 protein, C elegans
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Netrin-1
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netrin-2