Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

R E Brown; O Sergeeva; K S Eriksson; H L Haas

doi:10.1016/s0028-3908(00)00178-7

Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

Neuropharmacology. 2001 Mar;40(3):457-9. doi: 10.1016/s0028-3908(00)00178-7.

Authors

R E Brown¹, O Sergeeva, K S Eriksson, H L Haas

Affiliation

¹ Institut für Neurophysiologie, Heinrich-Heine-Universität, D-40001, Düsseldorf, Germany. brown@uni-duesseldorf.de

PMID: 11166339
DOI: 10.1016/s0028-3908(00)00178-7

Abstract

Orexin A (10-300 nM) strongly excited dorsal raphe serotonergic neurons maintained in vitro. The depolarization persisted in the presence of tetrodotoxin (TTX, 0.5 microM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy.

MeSH terms

Action Potentials / drug effects
Action Potentials / physiology
Animals
Appetite Regulation / physiology
Carrier Proteins / pharmacology*
In Vitro Techniques
Intracellular Signaling Peptides and Proteins*
Male
Narcolepsy / metabolism
Neurons / cytology
Neurons / drug effects*
Neurons / metabolism
Neuropeptides / pharmacology*
Orexins
Patch-Clamp Techniques
Raphe Nuclei / cytology
Raphe Nuclei / drug effects*
Raphe Nuclei / metabolism
Rats
Rats, Wistar
Serotonin / metabolism*
Serotonin Receptor Agonists / pharmacology
Tetrodotoxin / pharmacology

Substances

Carrier Proteins
Intracellular Signaling Peptides and Proteins
Neuropeptides
Orexins
Serotonin Receptor Agonists
Serotonin
Tetrodotoxin