Abstract
GABA-mediated transmission is characterized by high variability of synaptic responses. Major contributors to this variability are: presynaptic factors, including release probability and number of release sites; factors that determine synaptic GABA transients in the cleft, including diffusion and the actions of GABA transporters; and postsynaptic factors, including GABA(A) receptors subtypes, their location and number, their modulation by endogenous and exogenous factors, and their interactions with postsynaptic-anchoring proteins.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carrier Proteins / physiology
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GABA Plasma Membrane Transport Proteins
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Humans
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Mammals
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Membrane Proteins / physiology
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Membrane Transport Proteins*
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Organic Anion Transporters*
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Phylogeny
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Protein Conformation
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Receptors, GABA-A / chemistry
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Receptors, GABA-A / genetics
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Receptors, GABA-A / physiology*
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Synapses / physiology*
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Synaptic Transmission
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gamma-Aminobutyric Acid / physiology*
Substances
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Carrier Proteins
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GABA Plasma Membrane Transport Proteins
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Membrane Proteins
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Membrane Transport Proteins
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Organic Anion Transporters
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Receptors, GABA-A
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gamma-Aminobutyric Acid