Integrin-associated protein (CD47) and its ligands

Trends Cell Biol. 2001 Mar;11(3):130-5. doi: 10.1016/s0962-8924(00)01906-1.

Abstract

Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol. Peptides containing a VVM motif in the C-terminal domain of thrombospondins are agonists for CD47, initiating heterotrimeric Gi protein signaling that augments the functions of integrins of the beta 1, beta 2 and beta 3 families, thus modulating a range of cell activities including platelet activation, cell motility and adhesion, and leukocyte adhesion, migration and phagocytosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / chemistry
  • Antigens, CD / metabolism*
  • Antigens, Differentiation*
  • CD47 Antigen
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism*
  • Cell Movement / physiology
  • Chemotaxis / physiology
  • Heterotrimeric GTP-Binding Proteins / metabolism*
  • Humans
  • Integrins / chemistry
  • Integrins / metabolism*
  • Leukocytes / chemistry
  • Ligands
  • Membrane Glycoproteins / chemistry*
  • Membrane Glycoproteins / metabolism
  • Muscle, Smooth / cytology
  • Muscle, Smooth / physiology
  • Neural Cell Adhesion Molecule L1*
  • Neural Cell Adhesion Molecules / chemistry*
  • Neural Cell Adhesion Molecules / metabolism
  • Phagocytosis / physiology
  • Protein Binding / physiology
  • Receptors, Immunologic*
  • Signal Transduction
  • Thrombospondins / chemistry*
  • Thrombospondins / metabolism

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • CD47 Antigen
  • CD47 protein, human
  • Carrier Proteins
  • Integrins
  • Ligands
  • Membrane Glycoproteins
  • Neural Cell Adhesion Molecule L1
  • Neural Cell Adhesion Molecules
  • Receptors, Immunologic
  • Thrombospondins
  • Heterotrimeric GTP-Binding Proteins