Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition

J Comput Neurosci. 2001 Jul-Aug;11(1):63-85. doi: 10.1023/a:1011204814320.

Abstract

Experimental evidence suggests that the maintenance of an item in working memory is achieved through persistent activity in selective neural assemblies of the cortex. To understand the mechanisms underlying this phenomenon, it is essential to investigate how persistent activity is affected by external inputs or neuromodulation. We have addressed these questions using a recurrent network model of object working memory. Recurrence is dominated by inhibition, although persistent activity is generated through recurrent excitation in small subsets of excitatory neurons. Our main findings are as follows. (1) Because of the strong feedback inhibition, persistent activity shows an inverted U shape as a function of increased external drive to the network. (2) A transient external excitation can switch off a network from a selective persistent state to its spontaneous state. (3) The maintenance of the sample stimulus in working memory is not affected by intervening stimuli (distractors) during the delay period, provided the stimulation intensity is not large. On the other hand, if stimulation intensity is large enough, distractors disrupt sample-related persistent activity, and the network is able to maintain a memory only of the last shown stimulus. (4) A concerted modulation of GABA(A) and NMDA conductances leads to a decrease of spontaneous activity but an increase of persistent activity; the enhanced signal-to-noise ratio is shown to increase the resistance of the network to distractors. (5) Two mechanisms are identified that produce an inverted U shaped dependence of persistent activity on modulation. The present study therefore points to several mechanisms that enhance the signal-to-noise ratio in working memory states. These mechanisms could be implemented in the prefrontal cortex by dopaminergic projections from the midbrain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Afferent Pathways / cytology
  • Afferent Pathways / drug effects
  • Afferent Pathways / physiology*
  • Cerebral Cortex / cytology
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / physiology*
  • Dopamine / metabolism
  • Excitatory Postsynaptic Potentials / physiology
  • Feedback
  • Memory, Short-Term / drug effects
  • Memory, Short-Term / physiology*
  • Models, Neurological*
  • Nerve Net / cytology
  • Nerve Net / drug effects
  • Nerve Net / physiology*
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology*
  • Neurons / cytology
  • Neurons / drug effects
  • Neurons / physiology*
  • Pattern Recognition, Visual / physiology
  • Photic Stimulation / methods
  • Psychomotor Performance / physiology
  • Receptors, AMPA / drug effects
  • Receptors, AMPA / metabolism
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / metabolism
  • Receptors, GABA-A / drug effects
  • Receptors, GABA-A / metabolism
  • Receptors, N-Methyl-D-Aspartate / drug effects
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Synapses / drug effects
  • Synapses / physiology
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology

Substances

  • Receptors, AMPA
  • Receptors, Dopamine
  • Receptors, GABA-A
  • Receptors, N-Methyl-D-Aspartate
  • Dopamine