Abstract
Rat perinatal (E20-P0) CA1 pyramidal neurons were either synaptically active or silent. We show here that, during this developmental period, active but not silent cells form recurrent axon-collaterals that invade the radiatum and the lacunosum moleculare strata. These recurrents were never observed in adult rats. We propose that these transient recurrent axons may participate in the activity-dependent modulation of the synaptogenesis
MeSH terms
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Aging / physiology*
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Animals
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Animals, Newborn
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Axons / drug effects
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Axons / physiology
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Axons / ultrastructure*
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Cell Differentiation / physiology*
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Cell Size / physiology
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Dendrites / drug effects
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Dendrites / physiology
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Dendrites / ultrastructure
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Electric Stimulation
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Excitatory Amino Acid Agonists / pharmacology
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Excitatory Amino Acid Antagonists / pharmacology
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Fetus
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GABA Antagonists / pharmacology
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Hippocampus / cytology
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Hippocampus / embryology*
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Hippocampus / growth & development
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Immunohistochemistry
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Lysine / analogs & derivatives*
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Lysine / pharmacokinetics
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Membrane Potentials / drug effects
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Membrane Potentials / physiology
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Nerve Net / cytology
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Nerve Net / embryology*
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Nerve Net / growth & development
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Pyramidal Cells / cytology*
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Pyramidal Cells / drug effects
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Pyramidal Cells / physiology
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Rats
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Rats, Wistar
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Receptors, GABA-A / drug effects
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Receptors, GABA-A / metabolism
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Receptors, N-Methyl-D-Aspartate / metabolism
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology*
Substances
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Excitatory Amino Acid Agonists
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Excitatory Amino Acid Antagonists
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GABA Antagonists
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Receptors, GABA-A
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Receptors, N-Methyl-D-Aspartate
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biocytin
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Lysine