Cracking the transcriptional code for cell specification in the neural tube

T Marquardt; S L Pfaff

doi:10.1016/s0092-8674(01)00499-8

Cracking the transcriptional code for cell specification in the neural tube

Cell. 2001 Sep 21;106(6):651-4. doi: 10.1016/s0092-8674(01)00499-8.

Authors

T Marquardt¹, S L Pfaff

Affiliation

¹ Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

PMID: 11572771
DOI: 10.1016/s0092-8674(01)00499-8

Abstract

The bHLH repressor Olig2 participates in the transcriptional code governing cell fate specification in the ventral spinal cord. By temporally selective interactions with other transcription factors, Olig2 first directs motor neuron fate and later switches to promoting oligodendrocyte production.

Publication types

Review

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Cycle
Cell Differentiation
Central Nervous System / cytology
Central Nervous System / embryology*
Helix-Loop-Helix Motifs
Nerve Tissue Proteins / metabolism*
Neuroglia / cytology*
Neurons / cytology*
Spinal Cord / cytology
Spinal Cord / embryology*
Transcription Factors / metabolism
Transcription, Genetic*

Substances

Basic Helix-Loop-Helix Transcription Factors
Nerve Tissue Proteins
Transcription Factors