Abstract
The Notch signalling pathway defines a phylogenetically conserved cell-cell communication process that enables cell-fate specification in multicellular organisms. Deltex is a component of the Notch signalling network that physically interacts with the ankyrin repeats of Notch. Here, we report on the expression pattern of the Deltex1 gene during mouse embryonic development and, furthermore, we compare its expression with that of the Notch1, 2 and 3 genes. Complementary and combinatorial expression patterns between Deltex1 and the three Notch genes were observed throughout embryogenesis since Deltex1 expression was related either to cytodifferentiation (i.e. neuronal tissues) or to cell proliferation events (i.e. eye, vascular structures, hematopoiesis).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carrier Proteins*
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Cell Differentiation
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Cell Division
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Embryo, Mammalian / metabolism
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Eye / embryology
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In Situ Hybridization
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Membrane Proteins / biosynthesis*
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Mice
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Olfactory Mucosa / embryology
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Protein Biosynthesis*
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Proteins / genetics*
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Proto-Oncogene Proteins / biosynthesis*
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Receptor, Notch1
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Receptor, Notch2
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Receptor, Notch4
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Receptors, Cell Surface / biosynthesis*
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Receptors, Notch
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Signal Transduction
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Thymus Gland / embryology
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Time Factors
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Tissue Distribution
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Transcription Factors*
Substances
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Carrier Proteins
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Membrane Proteins
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Notch1 protein, mouse
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Notch2 protein, mouse
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Proteins
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Proto-Oncogene Proteins
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Receptor, Notch1
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Receptor, Notch2
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Receptor, Notch4
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Receptors, Cell Surface
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Receptors, Notch
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Transcription Factors
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deltex protein, vertebrate
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Notch4 protein, mouse