Group 2 metabotropic glutamate receptors induced long term depression in mouse striatal slices

Neurosci Lett. 2001 Dec 28;316(3):178-82. doi: 10.1016/s0304-3940(01)02397-7.

Abstract

We studied the roles of mGlu2/3 receptors (mGlu2/3) in glutamatergic transmission at corticostriatal synapses in mice brain slices. Perfusion of the selective mGlu2/3 agonists LY354740 and L-CCG1 caused the long term depression (LTD) of evoked synaptic responses. Photonic and electronic microscopy showed mGlu2/3 on axonal fibers and glial processes but not on striatal dendrites. mGlu2/3-LTD was independent of synaptic activity and insensitive to specific antagonists of dopamine D1, D2, GABA(B), N-methyl-D-aspartate or adenosine A1 receptors. Manipulation of the cAMP/protein kinase A cascade had no effect on the mGlu2/3-LTD. In contrast, MEK1-2 inhibitors reduced both mGlu2/3 initial depression and LTD suggesting the involvement of the mitogen activated kinase pathway in mGlu2/3-LTD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic Antagonists / pharmacology
  • Animals
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism*
  • Cerebral Cortex / ultrastructure
  • Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Dendrites / drug effects
  • Dendrites / metabolism
  • Dendrites / ultrastructure
  • Dopamine Antagonists / pharmacology
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Amino Acid Antagonists / pharmacology
  • Fluorescent Antibody Technique
  • GABA Antagonists / pharmacology
  • Glutamic Acid / metabolism*
  • MAP Kinase Kinase 1
  • Male
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Electron
  • Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Neostriatum / drug effects
  • Neostriatum / metabolism*
  • Neostriatum / ultrastructure
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology*
  • Neural Pathways / drug effects
  • Neural Pathways / metabolism*
  • Neural Pathways / ultrastructure
  • Neuroglia / drug effects
  • Neuroglia / metabolism
  • Neuroglia / ultrastructure
  • Neuronal Plasticity / drug effects
  • Neuronal Plasticity / physiology
  • Presynaptic Terminals / drug effects
  • Presynaptic Terminals / metabolism*
  • Presynaptic Terminals / ultrastructure
  • Protein Serine-Threonine Kinases / antagonists & inhibitors
  • Protein Serine-Threonine Kinases / metabolism
  • Receptors, Metabotropic Glutamate / drug effects
  • Receptors, Metabotropic Glutamate / metabolism*
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology

Substances

  • Adrenergic Antagonists
  • Dopamine Antagonists
  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • GABA Antagonists
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor 2
  • Glutamic Acid
  • Protein Serine-Threonine Kinases
  • Cyclic AMP-Dependent Protein Kinases
  • MAP Kinase Kinase 1
  • Map2k1 protein, mouse
  • Mitogen-Activated Protein Kinase Kinases