Abstract
The present study examined opioid receptor(s) mediation of feeding elicited by mu opioid agonists in the ventral tegmental area using general or selective opioid antagonist pretreatment. Naltrexone as well as equimolar doses of selective mu and kappa, but not delta opioid antagonists in the ventral tegmental area significantly reduced mu agonist-induced feeding, indicating a pivotal role for these receptor subtypes in the full expression of this response.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Appetite Regulation / drug effects
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Appetite Regulation / physiology*
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Dose-Response Relationship, Drug
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / pharmacology
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Feeding Behavior / drug effects
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Feeding Behavior / physiology*
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Male
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Naltrexone / analogs & derivatives*
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Naltrexone / pharmacology
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Narcotic Antagonists / pharmacology*
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Narcotics / pharmacology*
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Neural Pathways / drug effects
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Neural Pathways / metabolism
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Neurons / drug effects
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Neurons / metabolism*
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptors, Opioid, delta / agonists
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Receptors, Opioid, delta / antagonists & inhibitors
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Receptors, Opioid, delta / metabolism
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Receptors, Opioid, kappa / agonists
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Receptors, Opioid, kappa / antagonists & inhibitors
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Receptors, Opioid, kappa / metabolism
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Receptors, Opioid, mu / agonists
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Receptors, Opioid, mu / antagonists & inhibitors
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Receptors, Opioid, mu / metabolism*
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
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Ventral Tegmental Area / drug effects
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Ventral Tegmental Area / metabolism*
Substances
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Narcotic Antagonists
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Narcotics
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Receptors, Opioid, delta
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Receptors, Opioid, kappa
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Receptors, Opioid, mu
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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norbinaltorphimine
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Naltrexone
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beta-funaltrexamine
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naltrindole