Abstract
The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Active Transport, Cell Nucleus
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Animals
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Catalytic Domain
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Cell Nucleus / metabolism
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Cytoplasm / metabolism
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Enzyme Activation
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Gene Expression Regulation
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Humans
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I-kappa B Kinase
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NF-kappa B / metabolism*
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Protein Serine-Threonine Kinases / metabolism
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Signal Transduction
Substances
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NF-kappa B
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Protein Serine-Threonine Kinases
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CHUK protein, human
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I-kappa B Kinase
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IKBKB protein, human
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IKBKE protein, human