The bound leading the bound: target-derived receptors act as guidance cues

Neuron. 2002 Oct 24;36(3):333-5. doi: 10.1016/s0896-6273(02)01009-7.

Abstract

Developing axons are guided to their targets by chemoattractive and chemorepulsive ligands. Ledda et al., in this issue of Neuron, demonstrate that the target-derived receptor glial cell line-derived neurotrophic factor receptor alpha1 (GFRalpha1) can also act in trans as an axon guidance molecule for neurons.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Communication / physiology*
  • Cell Differentiation / physiology*
  • Chemotaxis / physiology*
  • Cues
  • Drosophila Proteins*
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Growth Cones / metabolism*
  • Humans
  • Nerve Growth Factors / metabolism
  • Nervous System / embryology*
  • Nervous System / metabolism
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases / metabolism*

Substances

  • Drosophila Proteins
  • GDNF protein, human
  • GFRA1 protein, human
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Nerve Growth Factors
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases
  • Ret protein, Drosophila