A mutant exhibiting abnormal habituation behavior in Caenorhabditis elegans

J Neurogenet. 2002 Jan-Mar;16(1):29-44. doi: 10.1080/01677060213105.

Abstract

The acquisition and retention of information by the nervous system are major processes of learning. Habituation is a simple learning process that occurs during repeated exposure to harmless stimuli. C. elegans is habituated when repeatedly given mechanical stimuli and recover from the habituation when the stimuli are stopped. A habituation abnormal mutant was isolated and assigned to a new gene hab-1 whose mutation causes slow habituation. The hab-1 mutant phenotype is remarkable at short time interval stimuli. However, hab-1 mutant worms show normal dishabituation. Ablations of neurons constituting the neural circuit for mechanical reflexes did not abolish abnormalities caused by the hab-1 mutation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / physiology*
  • Habituation, Psychophysiologic / genetics*
  • Models, Neurological
  • Mutation*
  • Nerve Net / physiology
  • Neurons / physiology
  • Physical Stimulation / methods
  • Reflex / physiology
  • Touch