Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease

J Clin Invest. 2002 Nov;110(10):1375-81. doi: 10.1172/JCI16783.
No abstract available

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / etiology
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / therapy
  • Amino Acid Sequence
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / genetics*
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Aspartic Acid Endopeptidases
  • Brain / metabolism
  • Endopeptidases / genetics
  • Endopeptidases / metabolism
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Models, Biological
  • Molecular Sequence Data
  • Mutation
  • Presenilin-1
  • Presenilin-2
  • Receptors, Notch

Substances

  • Amyloid beta-Peptides
  • Membrane Proteins
  • PSEN1 protein, human
  • PSEN2 protein, human
  • Presenilin-1
  • Presenilin-2
  • Receptors, Notch
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human