Abstract
Dickkopf-1 (Dkk-1) is a potent head inducer in Xenopus. This effect can be attributed to its capability to specifically inhibit Wnt/beta-catenin signalling. Recent data point to a crucial role for Dkk-1 in the control of programmed cell death during vertebrate limb development. In this paper, we present a comparative expression analysis of Dkk-1, Bmp-4 and Sox-9 as well as data on the regulation of Dkk-1 by Wnt. Finally, we summarize the current knowledge of its potential function in the developing limb and present a model how the interplay of the Bmp, Fgf and Wnt signalling pathways might differentially regulate programmed cell death versus chondrogenic differentiation in limb mesodermal cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis / physiology*
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Bone Morphogenetic Protein 4
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Bone Morphogenetic Proteins / physiology
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Cartilage / embryology*
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Embryonic Induction / physiology
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Extremities / embryology*
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Fibroblast Growth Factors / physiology
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Intercellular Signaling Peptides and Proteins
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Limb Buds
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Mice
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Protein Biosynthesis
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Proteins / genetics
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Proteins / physiology*
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Proto-Oncogene Proteins / physiology
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Wnt Proteins
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Xenopus Proteins
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Zebrafish Proteins*
Substances
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Bmp4 protein, mouse
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Bone Morphogenetic Protein 4
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Bone Morphogenetic Proteins
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Dkk1 protein, mouse
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Intercellular Signaling Peptides and Proteins
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Proteins
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Proto-Oncogene Proteins
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Wnt Proteins
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Xenopus Proteins
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Zebrafish Proteins
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bmp4 protein, Xenopus
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bmp4 protein, zebrafish
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dkk1b protein, zebrafish
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Fibroblast Growth Factors