A developmental switch in the signaling cascades for LTP induction

Nat Neurosci. 2003 Jan;6(1):15-6. doi: 10.1038/nn985.

Abstract

Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We report here that, unlike LTP in the more mature CA1 region of the hippocampus, LTP in neonatal rodent hippocampus (<9 postnatal days, <P9) requires cyclic AMP-dependent protein kinase A (PKA) but not Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

MeSH terms

  • Animals
  • Animals, Newborn
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors
  • Calcium-Calmodulin-Dependent Protein Kinases / genetics
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Carrier Proteins / pharmacology
  • Colforsin / pharmacology
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology
  • Excitatory Postsynaptic Potentials / drug effects
  • Excitatory Postsynaptic Potentials / physiology
  • Hippocampus / enzymology*
  • Hippocampus / growth & development*
  • Intracellular Signaling Peptides and Proteins*
  • Long-Term Potentiation / drug effects
  • Long-Term Potentiation / physiology*
  • Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Mutation / genetics
  • Neural Pathways / enzymology*
  • Neural Pathways / growth & development*
  • Neurons / enzymology*
  • Peptide Fragments / pharmacology
  • Rats
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology

Substances

  • Carrier Proteins
  • Enzyme Inhibitors
  • Intracellular Signaling Peptides and Proteins
  • Peptide Fragments
  • protein kinase modulator
  • Colforsin
  • Cyclic AMP-Dependent Protein Kinases
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Mitogen-Activated Protein Kinase 1