Abstract
Group-housed Sprague-Dawley (SD) rats exposed for 1 h to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT, a component of fox feces) did not display changes in hippocampal serotonin (5-HT) metabolism and [3H]5-HT reuptake, compared to water or butyric acid. Such an observation extended to isolated SD and Fischer 344 rats. When group-housed SD rats were tested 1 week after a 1-h exposure to TMT, hippocampal 5-HT metabolism, [3H]5-HT reuptake, and [3H]paroxetine binding at the 5-HT transporter remained unchanged. This study questions TMT as a specific predatory stimulus as both butyric acid and TMT increased plasma corticosterone levels whilst leaving intact open field behaviour (at least in group-housed SD rats).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carrier Proteins / metabolism
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Corticosterone / metabolism*
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Foxes / physiology*
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Hippocampus / drug effects
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Hippocampus / metabolism*
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Male
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Membrane Glycoproteins / metabolism
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Membrane Transport Proteins*
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Motor Activity / drug effects
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Motor Activity / physiology*
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Nerve Tissue Proteins*
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Odorants*
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Paroxetine / metabolism
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Rats / physiology*
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Rats, Inbred F344
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Rats, Sprague-Dawley
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Selective Serotonin Reuptake Inhibitors / metabolism
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Serotonin / metabolism*
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Serotonin Plasma Membrane Transport Proteins
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Thiazoles / pharmacology
Substances
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2,5-dihydro-2,4,5-trimethylthiazoline
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Carrier Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Serotonin Plasma Membrane Transport Proteins
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Serotonin Uptake Inhibitors
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Slc6a4 protein, rat
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Thiazoles
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Serotonin
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Paroxetine
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Corticosterone