Abstract
Significant progress has been made over the past several years on structural studies of the eukaryotic translation initiation factors that facilitate the assembly of a translation-competent ribosome at the initiation codon of an mRNA. These structural studies have revealed the repeated use of a set of common structural folds, highlighted the evolutionary conservation of the translation apparatus, and provided insight into the mechanism and regulation of cellular and viral protein synthesis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Binding Sites
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Eukaryotic Initiation Factor-2 / chemistry
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Eukaryotic Initiation Factor-2 / metabolism
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Eukaryotic Initiation Factor-4E / chemistry
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Eukaryotic Initiation Factor-4E / metabolism
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Eukaryotic Initiation Factor-4G / genetics
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Eukaryotic Initiation Factor-4G / metabolism
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Eukaryotic Initiation Factors / chemistry*
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Eukaryotic Initiation Factors / metabolism
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Gene Expression Regulation / physiology
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Homeostasis / physiology
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Macromolecular Substances
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Models, Molecular*
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Phosphorylation
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Poly(A)-Binding Proteins / chemistry*
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Poly(A)-Binding Proteins / metabolism
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Protein Binding
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Protein Biosynthesis / physiology
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Protein Conformation
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Protein Structure, Tertiary
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RNA, Ribosomal / chemistry*
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RNA, Transfer / chemistry*
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RNA, Transfer / metabolism
Substances
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Eukaryotic Initiation Factor-2
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Eukaryotic Initiation Factor-4E
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Eukaryotic Initiation Factor-4G
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Eukaryotic Initiation Factors
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Macromolecular Substances
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Poly(A)-Binding Proteins
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RNA, Ribosomal
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RNA, Transfer