Abstract
Axon growth inhibitors associated with myelin and the glial scar contribute to the failure of axon regeneration in the injured adult mammalian central nervous system (CNS). A number of these inhibitors, their receptors, and signaling pathways have been identified. These inhibitors can now be neutralized by a variety of approaches that point to the possibility of developing new therapeutic strategies to stimulate regeneration after spinal cord injury.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Axons / physiology
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Cicatrix / metabolism
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Humans
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In Vitro Techniques
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Molecular Biology*
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Myelin Proteins / metabolism
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Myelin Sheath / physiology
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Myelin-Associated Glycoprotein / metabolism
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Nerve Regeneration / physiology*
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Neural Inhibition
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Nogo Proteins
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Signal Transduction / physiology
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Spinal Cord Injuries* / genetics
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Spinal Cord Injuries* / physiopathology
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Spinal Cord Injuries* / therapy
Substances
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Myelin Proteins
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Myelin-Associated Glycoprotein
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Nogo Proteins
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RTN4 protein, human