Biology of FasL

Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):325-35. doi: 10.1016/s1359-6101(03)00028-5.

Abstract

FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of these molecules in the disease. Once thought to be mainly involved in the homeostasis of immune system, the territory of FasL regulation has been expanded to angiogenesis and tumor progression. Here, we review what is currently known about the role of FasL in many areas of biology.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantibodies / biosynthesis
  • Cytotoxicity, Immunologic
  • Fas Ligand Protein
  • Homeostasis
  • Humans
  • Immune Tolerance
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / immunology
  • Membrane Glycoproteins / physiology*
  • Mice
  • Mice, Mutant Strains
  • Models, Immunological
  • Mutation
  • Neoplasms / immunology
  • Neovascularization, Pathologic
  • T-Lymphocytes / immunology

Substances

  • Autoantibodies
  • FASLG protein, human
  • Fas Ligand Protein
  • Fasl protein, mouse
  • Membrane Glycoproteins