Effect of antibodies to morphine on synaptic plasticity of the hippocampus

N A Beregovoi; T M Pankova; N S Sorokina; M V Starostina

doi:10.1023/a:1023895109474

Effect of antibodies to morphine on synaptic plasticity of the hippocampus

Bull Exp Biol Med. 2003 Feb;135(2):114-6. doi: 10.1023/a:1023895109474.

Authors

N A Beregovoi¹, T M Pankova, N S Sorokina, M V Starostina

Affiliation

¹ Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. beka@cyber.ma.nsc.ru

PMID: 12802411
DOI: 10.1023/a:1023895109474

Abstract

Incubation of hippocampal slices with antibodies to morphine did not change the total excitatory postsynaptic potential of mossy fibers, but markedly facilitated long-term posttetanic potentiation. Culturing of the organotypic hippocampal culture in the presence of 10 microM morphine increased the total excitatory postsynaptic potential of mossy fibers and reduced the probability of long-term posttetanic potentiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies / immunology
Antibodies / metabolism*
Excitatory Postsynaptic Potentials / physiology
Hippocampus / cytology
Hippocampus / metabolism*
In Vitro Techniques
Long-Term Potentiation / physiology
Morphine / immunology*
Neuronal Plasticity / physiology*
Rats
Rats, Wistar

Substances

Antibodies
Morphine