MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing

Cell. 2003 Jun 13;113(6):673-6. doi: 10.1016/s0092-8674(03)00428-8.

Abstract

Drosophila geneticists have uncovered roles for microRNAs in the coordination of cell proliferation and cell death during development, and in stress resistance and fat metabolism. In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / growth & development
  • Cell Division / genetics
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / growth & development
  • Gene Expression Regulation, Developmental / genetics
  • MicroRNAs / genetics*
  • Protein Biosynthesis / genetics
  • RNA, Messenger / genetics*

Substances

  • MicroRNAs
  • RNA, Messenger