Abstract
Ghrelin stimulates feeding when administered centrally and peripherally. The lateral hypothalamus (LH) is thought to mediate ghrelin-induced hyperphagia. Thus, we examined central mechanisms underlying feeding generated by LH ghrelin. We determined that 0.3nmol of LH-injected ghrelin was the lowest dose increasing food consumption and it induced Fos immunoreactivity (IR; a marker of neuronal activation) in feeding-related brain areas, including the hypothalamic paraventricular, arcuate, and dorsomedial nuclei, amygdala, and nucleus of the solitary tract. Also, LH ghrelin induced Fos IR in LH orexin neurons. We conclude that the LH, as part of larger central circuitry, integrates orexigenic properties of ghrelin.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amygdala / drug effects
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Amygdala / pathology
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Animals
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Brain / pathology
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Carrier Proteins / metabolism
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Dose-Response Relationship, Drug
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Ghrelin
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Hypothalamus / drug effects*
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Hypothalamus / metabolism
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Hypothalamus / pathology*
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Immunohistochemistry
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Intracellular Signaling Peptides and Proteins*
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Ligands
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Male
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Neurons / metabolism*
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Neuropeptides / metabolism
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Oncogene Proteins v-fos / metabolism
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Orexin Receptors
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Orexins
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Peptide Hormones / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Receptors, G-Protein-Coupled / chemistry
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Receptors, Ghrelin
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Receptors, Neuropeptide
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Time Factors
Substances
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Carrier Proteins
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Ghrelin
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Intracellular Signaling Peptides and Proteins
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Ligands
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Neuropeptides
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Oncogene Proteins v-fos
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Orexin Receptors
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Orexins
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Peptide Hormones
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Receptors, G-Protein-Coupled
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Receptors, Ghrelin
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Receptors, Neuropeptide