We investigated the possible changes in body temperature, heart frequency, and blood pressure in 22 residents sitting for the yearly exam at the Specialty School of Psychiatry at Pisa University. All subjects were then evaluated 2 or 3 weeks later, in calm situations. In a subgroup, a specific plasmatic diazepam binding inhibitor (BBIA), previously described, was also measured. The results showed that all subjects underwent significant stress-related changes in the parameters studied, which suggest the involvement of different mechanisms in preexam stress.